Rabu, 21 Desember 2016

UNAIR NEWS - Pencapaian sebuah prestasi bagi seseorang tentunya tidak luput dari usaha yang keras. Untuk melakukannya pun harus dilandasi sikap yang disiplin. Kesibukan skripsi dan menjelang kelulusan, tidak lekas menjadi sebuah penghalang, Silvester Sili Teka, tak ragu menunjukkan prestasinya. Pada tanggal 1 Desember lalu, mahasiswa Fakutas Ilmu Sosial dan Politik ini kembali menorehkan prestasi di Kejuaraan Nasional Terbuka Piala Gubernur Jatim 2016. Dalam kejuaraan yang berlangsung di DBL Arena dan diikuti oleh 800 orang peserta ini, Silvester berhasil meraih Juara 1 kategori under 54kg senior putra, serta mempersembahkan medali emas sebagai hadiah ulang tahun bagi UKM Taekwondo UNAIR yang kini memasuki tahun ke-34.
Atlet yang pernah dinobatkan sebagai “Atlet Terbaik Senior Putra” di Kejuaraan Nasional Piala Kapolres Semarang yang berlangsung pada 11-13 November lalu itu mengungkapkan, taekwondo itu sudah menjadi hobbinya sejak lama.
“Sebagai bagian dari keluarga UKM Taekwondo UNAIR, kontribusi terhadap UKM menjadi sangat penting. Dan prestasi yang saya raih adalah berkat dukungan dan motivasi dari teman-teman UKM,” jelasnya.
Bagi Silvester, poin penting yang perlu diingat bahwa keberhasilan meraih prestasi juga merupakan sebuah pilihan. Artinya, jika memilih untuk menjadi seseorang yang berhasil, tentu ada harga dan pengorbanan yang perlu dibayar.
“Seberapa besar pencapaian yang kita raih akan berbanding lurus dengan besar pengorbanan yang kita upayakan. Seperti kata pepatah cina kuno yang berbunyi pencapaian besar selalu diawali dengan sebuah langkah kecil,” terangnya.
Selain itu, Silvester juga mengungkapkan bahwa pemenang bukanlah yang berada di puncak tertinggi, bukan yang berteriak paling kencang, bukan pula yang tak pernah merasakan pahitnya kegagalan. Namun, banginya pemenang adalah yang tidak menyerah dan ketika terjatuh akan senantiasa bangkit.
“Latihan seberat apapun itu, kalau kita jalani dengan tekad yang kuat, hasil apapun yang kita terima merupakan suatu kebanggan tersendiri bagi kita,” ujar Silvester. (*)
Penulis: Yosi Dwi Apriliani,  Mahasiswa Ekonomi Islam FEB UNAIR
Editor: Nuri Hermawan

Senin, 19 Desember 2016


In vitro cytotoxicity assay of Sauropus androgynus on human mesenchymal stem cells

a  Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia
b  Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia 
Abstract
Sauropus androgynus is a well-known Indonesian medicinal herb that is used extensively to increase human breast-milk production. However, many studies have also revealed side effects associated with bronchiolitis obliterans in Taiwan and Japan. The present study evaluated the in vitro toxic effects of S. androgynus on human mesenchymal stem cell culture derived from bone marrow (hMSCs-BM). This is the first report of a cytotoxicity assay of S. androgynus extracts from Indonesia. After 72 hours of incubating cell cultures with varying concentrations of extracts (250-2500 mg L-1), cytotoxicity was assayed by the reduction of 3-(4,5-dimethyl- thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and reported in terms of cell viability. The apoptotic effects of the extract were determined by a terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) colorimetric assay. The S. androgynus methanol extract from East Java, Indonesia, was less cytotoxic to hMSCs-BM with an IC50 of 2450 mg L-1, but it could inhibit cell viability via the apoptosis pathway. A sample extract of plants collected near Purwosari had the lowest hMSCs-BM viability percentage (37%), while the extract from plants collected near Surabaya Pusat had a cell viability of 75%. Further studies are required to investigate the metabolites in S. androgynus that are highly correlated with its toxic effects. © 2013 Copyright Taylor and Francis Group, LLC.

Full Text :


Does phallic masculinity still matter?: Masculinities in Indonesian teenlit during the post-reformasi period (1998-2007)

a  Faculty of Humanities, Universitas Airlangga, Surabaya, Indonesia b  

Abstract
This paper examines the representation of masculinities in commercial or popular Indonesian literature for young people published during the Post-Reformasi period. Within the climate of more open socio-political atmosphere of the period, the teenage literature shows more involvement of young female writers. While the representation of female protagonists indicates more progressive gender roles, the portrayal of male protagonists in teenlit written by female writers reflect a more conservative gender perspective. On the other hand, ways of being male in the form of literature written by male authors indicate the stream of masculinity derived from the Javanese aristocratic values (priyayi). This variant of masculinity, which was promoted actively in the previous regime (the New Order regime), shows signs of restraint. © 2013 by the Men's Studies Press, LLC.

Full Text :



Distribution of dimethylarginine-dimethylaminohydrolase-II (DDAH2) gene polymorphism in hemodialysis patients.

Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia. 

Abstract
to describe the distribution of single nucleotide polymorphisms (SNPs) at -449 (promoter region) DDAH 2 in hemodialysis (HD) patients. this study was a descriptive study, 56 HD patients and 30 healthy individuals were enrolled. Based on its etiology, the HD patient group was further divided into hypertension (HT) group and non-HT group. DNA was extracted from whole blood samples with a commercially available DNA isolation kit. Genotyping of the polymorphisms was performed using PCR-based SNP detection methods (Applied Biosystems, Carlsbad, USA) based on 5'-exonuclease activity assays for rs805305 (-449 G/C). Allelic variation was assessed in each participant. heterozygotes were observed as the most abundant genotypes in both groups (70% in healthy individuals and 55% in HD patients), followed by GG genotype in the HD patients (30%), while CC (27%) was the second most common genotype polymorphism in the healthy individuals. there is a significant difference in distribution of DDAH 2 gene polymorphism among HD patients compared to healthy individuals (p=0.01).

Full Text :


Estimation of children growth curve based on kernel smoothing in multi-response nonparametric regression

Mathematics Department, Faculty of Sciences and Technology, Airlangga University, Indonesia 

Abstract
Physical children growth is measured by using anthropometric measures i.e. weight, height and head circumference. The children around two years old grow rapidly, and than decrease slowly along with increasing of children age. It means that locally model approach is more appropriate to the data. Kernel smoothing is one of estimation methods in nonparametric regression. In this paper, we study about Kernel smoothing in multi-response nonparametric regression model and apply it for estimating children up to five years old growth. The model consists of three response variables i.e. weight, height and head circumference, and age as a predictor variable. For determining optimal bandwidth for each response variable, we use cross-validation method. Based on children data in Surabaya 2010, and the 50thpercentiles estimation of weight, height and head circumference versus age, we obtain the mean squared error value is 0.05583 and coefficient of determination is 99.99%. The estimation model of children growth curve based on multi-respon kernel smoothing shows fluctuation of the curve and gives mean squared error value tends to zero and coefficient of determination tends to one. These facts mean that the estimation has satisfied goodness of fit criterion. © 2013 Nur Chamidah and Toha Saifudin.

Full Text :


Bioaccumulation, elimination, and toxic effect of cadmium on structure of gills and hepatopancreas of freshwater prawn macrobrachium sintangese (De Man, 1898)

a  Department of Biology, Faculty of Sciences and Technology, Airlangga University, Jl. Mulyorejo, Surabaya 60115, Indonesia b  

Abstract
The objectives of this study were to determine the acute toxicity of cadmium and to examine the bioaccumulation and elimination of cadmium in different tissues of the freshwater prawn Macrobrachium sintangese. It also evaluated the structural damage of gills and hepatopancreas of M. sintangese when administered to sublethal cadmium concentration and when exposed prawns were transferred to cadmium-free media. According to the mortality data, the 96 h LC50 value of Cd to M. sintangese was 86 μg/L. The highest cadmium accumulation was observed in gills, followed by the hepatopancreas, and the abdominal muscle. After being transferred to cadmium-free media, the highest cadmium elimination was observed in abdominal muscle, followed by the gills and hepatopancreas. The gills of prawns exposed to cadmium exhibited a severe hyperplasia, vacuolization, and multiple necroses which resulted to the swelling of lamellae. After transferring the cadmium-exposed prawns into the control media, the histopathological effects decreased. Severe alterations to the hepatopancreatic tissue were observed in prawns exposed to cadmium. The tubular epithelial cells were heavily vacuolated and even ruptured. The number of large vacuoles and R cells appeared in the tubular epithelial cells of the hepatopancreas. After transferring to the control media, the histological alterations of the hepatopancreas decreased. The tubular epithelial cells began to rearrange to the normal structure. The number of R cells and B cells were noted in the epithelial cells. The thickness of tubular epithelial cells was comparable to the controls. Due to the sensitivity of M. sintangese to cadmium, therefore this species potentially can be used as a test organism in toxicity assays. © 2013 Springer Science+Business Media Dordrecht.
Author keywords
Bioaccumulation; Cadmium; Elimination; Gills; Hepatopancreas; Macrobrachium sintangese
Indexed keywords
Abdominal muscle; Elimination; Epithelial cells; Gills; Hepatopancreas; Macrobrachium sintangese; Normal structure; Structural damages
Engineering controlled terms: Bioaccumulation; Biochemistry; Cells; Muscle; Shellfish; Toxicity; Water
Engineering main heading: Cadmium
EMTREE drug terms: cadmium
GEOBASE Subject Index: bioaccumulation; cadmium; concentration (composition); crustacean; histopathology; mortality; toxicity
EMTREE medical terms: abdominal wall musculature; acute toxicity; anatomical variation; animal tissue; article; bioaccumulation; bioassay; cadmium poisoning; cell hyperplasia; cell swelling; cell vacuole; concentration (parameters); controlled study; disease severity; elimination reaction; freshwater species; gill; hepatopancreas; histopathology; kidney tubule cell; lamellar body; Macrobrachium; Macrobrachium sintangese; nonhuman; sensitivity analysis; tissue level; tissue necrosis
Species Index: Decapoda (Crustacea); Macrobrachium

Full Text :